Cosmofer®
Cosmofer® (low Mw iron dextran) is a treatment for iron deficiency anaemia
Cosmofer® is a parenteral iron formulation of low molecular
weight (Mw) iron dextran with a well-documented safety
profile.
Low Mw iron dextran has been used in more than 70
million doses1 and is characterized by significantly
less adverse events compared to high Mw iron
dextran.2,3,4,5,6,7
The formulation of Cosmofer® is characterized by a strong
colloidal complex of a ferric core shielded by dextran
chains.8 This gives a strong iron-carbohydrate complex,
which is more stable than iron sucrose and iron
gluconate.9,10,11,12
The tightly bound iron and the pH-neutral formulation are the
reasons why Cosmofer® low Mw iron dextran offers the
flexibility of parenteral iron administration, either as an
intravenous, intramuscular iron injection or as a total dose iron
infusion.8
As with the use of other parenteral iron treatments, the use of
Cosmofer® carries a risk of immediate severe and potentially lethal
anaphylactoid reactions.
Learn more about Cosmofer® at Cosmofer.com.
Important Safety Information
Any use of Cosmofer® should not be initiated without consulting
a physician and having read the full Cosmofer® Summary of Product
Characteristics.
References
1) IMS data and data on file Pharmacosmos. 2)
McCarthy et al., Am J Nephrol 2000; 20: 455-462. 3) Fletes R. et
al., American Journal of Kidney Diseases, Vol. 37, No. 4 (April),
2001: pp. 743-749. 4) Chertow GM et al., Nephrol Dial Transplant
2004; 19: 1571-1575. 5) Peck SN et al. Journal of Pediatric
Gastroenterology and Nutrition: Vol. 27 (4) Oct. 1998 p. 487. 6)
Case G. ANNA Journal; Feb. 1998; 25, 1 pp. 65-68. 7) Coyne D.W. et
al., Kidney International (2003) Vol. 63, pp. 217-224. 8) Summary
of products characteristics. Please contact your local distributor
to receive a copy of this information. 9) Geisser P et al.
Arzneimittelforschung/Drug Research (1992). 42 (II), 12, 1439-1452.
10) Zager RA et al. AJKD 2002, 40, (1): 90-103. 11) Zager RA et al.
Kidney International 2004, 66: 144-156. 12) Agarwal R, Kidney
International, Vol. 65 (2004), pp. 2279-2289.